What ACTH is
ACTH is a pituitary peptide hormone that drives adrenal steroid signaling and stress-axis physiology.
ACTH is grouped under Endogenous / Biology / Approved / Clinical on PeptideFactCheck because it is a core peptide for understanding the endocrine stress axis and the origin of several analog or fragment discussions.
The useful starting point is to separate the molecule itself from the internet story around it. It is a core peptide for understanding the endocrine stress axis and the origin of several analog or fragment discussions.
Why people keep looking it up
It is a core peptide for understanding the endocrine stress axis and the origin of several analog or fragment discussions.
ACTH is a pituitary peptide hormone that drives adrenal steroid signaling and stress-axis physiology.
ACTH tends to stay in the conversation because it touches a familiar public theme: pituitary peptide, adrenal axis, and stress signaling. That makes it easy for the claim to travel faster than the evidence.
What the evidence can support right now
Foundational endocrine peptide reference entry.
Human endocrine biology is well established, and some drug products or diagnostic uses connect back to this pathway.
Mechanistic support is extensive across HPA-axis physiology.
Why this page carries the current tier: Foundational endocrine peptide reference entry.
The current seed trail for ACTH is pulling from 2 databases sources and 1 literature source.
Safety, limits, and regulatory context
This is a complex endocrine-control peptide, not a casual optimization lever.
ACTH is tracked primarily as endogenous biology in this index.
Editorial boundary: PeptideFactCheck does not publish dosing, cycling, sourcing, injection, or administration instructions for ACTH. The job here is to explain the public claim, the mechanism story, the evidence strength, and the current limits.
Molecular and identifier data
The current PubChem match for ACTH is CID 16132265. That gives the page a source-backed chemistry record rather than a placeholder identifier block.
- PubChem CID
- 16132265
- Formula
- C207H308N56O58S
- Molecular weight
- 4541
- InChIKey
- IDLFZVILOHSSID-OVLDLUHVSA-N
Matched synonyms include corticotropin, Corticotrophin, Cortrophin, Acthar, Adrenocorticotropin, Adrenocorticotrophin, H.P. Acthar gel, Corticotrofina.
Open PubChem recordClinical trial snapshot
The current ClinicalTrials.gov intervention query for ACTH returns 341 study records. This does not prove efficacy by itself, but it does show whether the peptide is showing up in a formal trial registry rather than only in forums or vendor copy.
Literature snapshot
The current PubMed query for ACTH returns 80735 results. The articles below are a quick literature surface so the page shows actual papers instead of only generic evidence labels.
Label and regulatory records
For approved or clinically developed peptides, the page now pulls in official labeling and FDA-facing records where they exist. That makes the regulatory section materially more useful than a generic approved or not-approved tag.
- Brand names
- Adrenal Liquescence 3001
- Generic names
- ADRENAL LIQUESCENCE
- Routes
- ORAL
- Application numbers
- Not linked
Indications and usage. INDICATIONS For the temporary relief of lethargy, lack of energy, sadness, anxiousness, or decreased ability to handle stress.*
Source trail
Each linked source is shown directly so the page can be audited. The page now combines its editorial seed trail with automated official-source enrichment generated on 2026-04-24 from PubChem, ClinicalTrials.gov, PubMed, DailyMed, openFDA label, and Drugs@FDA.