What Humanin is
Humanin is a mitochondrial-derived peptide discussed in stress-response, cytoprotection, and aging-biology research.
Humanin is grouped under Longevity + Skin / Endogenous / Biology on PeptideFactCheck because it sits beside MOTS-c in the category of mitochondrial peptides that sound like direct levers on aging biology.
The useful starting point is to separate the molecule itself from the internet story around it. It sits beside MOTS-c in the category of mitochondrial peptides that sound like direct levers on aging biology.
Why people keep looking it up
It sits beside MOTS-c in the category of mitochondrial peptides that sound like direct levers on aging biology.
Humanin is a mitochondrial-derived peptide discussed in stress-response, cytoprotection, and aging-biology research.
Humanin tends to stay in the conversation because it touches a familiar public theme: mitochondrial peptide, cell stress, and aging biology. That makes it easy for the claim to travel faster than the evidence.
What the evidence can support right now
Promising mitochondrial peptide biology with mostly preclinical support for longevity claims.
The biology is interesting, but human therapeutic evidence remains limited.
Preclinical and mechanistic work drive most of the current interest.
Why this page carries the current tier: Promising mitochondrial peptide biology with mostly preclinical support for longevity claims.
The current seed trail for Humanin is pulling from 2 databases sources and 1 literature source.
Safety, limits, and regulatory context
Mitochondrial-aging claims are compelling but can become speculative very quickly.
Humanin is tracked here as endogenous biology rather than an approved medicine.
Editorial boundary: PeptideFactCheck does not publish dosing, cycling, sourcing, injection, or administration instructions for Humanin. The job here is to explain the public claim, the mechanism story, the evidence strength, and the current limits.
Molecular and identifier data
The current PubChem match for Humanin is CID 16131438. That gives the page a source-backed chemistry record rather than a placeholder identifier block.
- PubChem CID
- 16131438
- Formula
- C119H204N34O32S2
- Molecular weight
- 2687.2
- InChIKey
- DPEUWKZJZIPZKE-OFANTOPUSA-N
Matched synonyms include Humanin, 330936-69-1, H975EUX36G, DTXSID70186749, RefChem:146895, DTXCID60109240, HUMANIN TRIFLUOROACETATE, formyl humanin.
Open PubChem recordClinical trial snapshot
The current ClinicalTrials.gov intervention query for Humanin returns 2 study records. This does not prove efficacy by itself, but it does show whether the peptide is showing up in a formal trial registry rather than only in forums or vendor copy.
Literature snapshot
The current PubMed query for Humanin returns 538 results. The articles below are a quick literature surface so the page shows actual papers instead of only generic evidence labels.
Source trail
Each linked source is shown directly so the page can be audited. The page now combines its editorial seed trail with automated official-source enrichment generated on 2026-04-24 from PubChem, ClinicalTrials.gov, PubMed, DailyMed, openFDA label, and Drugs@FDA.