What Palmitoyl Pentapeptide-4 is
Palmitoyl pentapeptide-4 is a cosmetic peptide discussed in collagen and skin-appearance marketing, usually in topical formulations.
Palmitoyl Pentapeptide-4 is grouped under Longevity + Skin on PeptideFactCheck because it is one of the best-known cosmetic peptides for anti-aging skin claims.
The useful starting point is to separate the molecule itself from the internet story around it. It is one of the best-known cosmetic peptides for anti-aging skin claims.
Why people keep looking it up
It is one of the best-known cosmetic peptides for anti-aging skin claims.
Palmitoyl pentapeptide-4 is a cosmetic peptide discussed in collagen and skin-appearance marketing, usually in topical formulations.
Palmitoyl Pentapeptide-4 tends to stay in the conversation because it touches a familiar public theme: cosmetic peptide, collagen discussion, and topical skin. That makes it easy for the claim to travel faster than the evidence.
What the evidence can support right now
Well-known cosmetic peptide with modest evidence and heavy marketing.
Evidence is usually product-level or cosmetic rather than strong medical-grade clinical proof.
The main support is mechanistic skin-matrix logic and cosmetic-study literature.
Why this page carries the current tier: Well-known cosmetic peptide with modest evidence and heavy marketing.
The current seed trail for Palmitoyl Pentapeptide-4 is pulling from 1 literature source, 1 trials source, and 1 databases source.
Safety, limits, and regulatory context
Topical appearance claims should not be confused with deep tissue or systemic anti-aging evidence.
This is not tracked here as a clear FDA-approved peptide drug.
Editorial boundary: PeptideFactCheck does not publish dosing, cycling, sourcing, injection, or administration instructions for Palmitoyl Pentapeptide-4. The job here is to explain the public claim, the mechanism story, the evidence strength, and the current limits.
Molecular and identifier data
The current PubChem match for Palmitoyl Pentapeptide-4 is CID 9897237. That gives the page a source-backed chemistry record rather than a placeholder identifier block.
- PubChem CID
- 9897237
- Formula
- C39H75N7O10
- Molecular weight
- 802.1
- InChIKey
- WSGCRSMLXFHGRM-DEVHWETNSA-N
Matched synonyms include 214047-00-4, Palmitoyl Pentapeptide-4, L-Serine, N2-(1-oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-, Palmitoyl pentapeptide-3, Oristar popp, Lipopentapeptide 3, PAL-Lys-Thr-Thr-Lys-Ser, Palmitoyl pentapeptide-4 [INCI].
Open PubChem recordClinical trial snapshot
The current ClinicalTrials.gov intervention query for Palmitoyl Pentapeptide-4 returns 0 study records. This does not prove efficacy by itself, but it does show whether the peptide is showing up in a formal trial registry rather than only in forums or vendor copy.
No linked intervention records were returned by the current ClinicalTrials.gov query terms for this page.
Literature snapshot
The current PubMed query for Palmitoyl Pentapeptide-4 returns 29 results. The articles below are a quick literature surface so the page shows actual papers instead of only generic evidence labels.
Label and regulatory records
For approved or clinically developed peptides, the page now pulls in official labeling and FDA-facing records where they exist. That makes the regulatory section materially more useful than a generic approved or not-approved tag.
- Brand names
- Stretch Marks cream
- Generic names
- SESAMUM INDICUM (SESAME) SEED EXTRACT,PRUNUS PERSICA (PEACH) RESIN EXTRACT,STERCULIA URENS GUM,TRIPEPTIDE-1,HEXAPEPTIDE-9,ACETYL TETRAPEPTIDE-9,PALMITOYL PENTAPEPTIDE-4,PALMITOYL TETRAPEPTIDE-7,ACETYL HEXAPEPTIDE-8.
- Routes
- TOPICAL
- Application numbers
- M016
Indications and usage. INDICATIONS & USAGE Stretch Marks cream,removes scars, repairs, and enhances skin elasticity. Apply all over the body, concentrating on the abdomen. Apply to skin every morning and evening.
Source trail
Each linked source is shown directly so the page can be audited. The page now combines its editorial seed trail with automated official-source enrichment generated on 2026-04-24 from PubChem, ClinicalTrials.gov, PubMed, DailyMed, openFDA label, and Drugs@FDA.