What Orexin-A is
Orexin-A is an endogenous neuropeptide involved in wakefulness, arousal, feeding behavior, and neuroendocrine regulation.
Orexin-A is grouped under Endogenous / Biology on PeptideFactCheck because it matters because peptide biology reaches deeply into sleep and arousal systems, not just metabolism and muscle.
The useful starting point is to separate the molecule itself from the internet story around it. It matters because peptide biology reaches deeply into sleep and arousal systems, not just metabolism and muscle.
Why people keep looking it up
It matters because peptide biology reaches deeply into sleep and arousal systems, not just metabolism and muscle.
Orexin-A is an endogenous neuropeptide involved in wakefulness, arousal, feeding behavior, and neuroendocrine regulation.
Orexin-A tends to stay in the conversation because it touches a familiar public theme: wakefulness, appetite, and neuropeptide. That makes it easy for the claim to travel faster than the evidence.
What the evidence can support right now
High-confidence neuropeptide biology reference entry.
Human biology is well established, especially in sleep medicine context.
Mechanistic support across arousal and feeding physiology is extensive.
Why this page carries the current tier: High-confidence neuropeptide biology reference entry.
The current seed trail for Orexin-A is pulling from 2 databases sources and 1 literature source.
Safety, limits, and regulatory context
This is primarily a biology-reference entry, not a straightforward intervention peptide.
Orexin-A is tracked here as endogenous biology.
Editorial boundary: PeptideFactCheck does not publish dosing, cycling, sourcing, injection, or administration instructions for Orexin-A. The job here is to explain the public claim, the mechanism story, the evidence strength, and the current limits.
Molecular and identifier data
The current PubChem match for Orexin-A is CID 56842143. That gives the page a source-backed chemistry record rather than a placeholder identifier block.
- PubChem CID
- 56842143
- Formula
- C152H243N47O44S4
- Molecular weight
- 3561.1
- InChIKey
- OFNHNCAUVYOTPM-IIIOAANCSA-N
Matched synonyms include Orexin A, orexin-A, Orexine A, Hypocretin 1, 8RDY08V4VC, 205599-75-3, hypocretin-1, RefChem:928255.
Open PubChem recordClinical trial snapshot
The current ClinicalTrials.gov intervention query for Orexin-A returns 71 study records. This does not prove efficacy by itself, but it does show whether the peptide is showing up in a formal trial registry rather than only in forums or vendor copy.
Literature snapshot
The current PubMed query for Orexin-A returns 2340 results. The articles below are a quick literature surface so the page shows actual papers instead of only generic evidence labels.
Source trail
Each linked source is shown directly so the page can be audited. The page now combines its editorial seed trail with automated official-source enrichment generated on 2026-04-24 from PubChem, ClinicalTrials.gov, PubMed, DailyMed, openFDA label, and Drugs@FDA.